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A 75-year-old man has been arrested in connection with the bombing of McGurk's Bar in 1971.
The man was taken to the Antrim Serious Crime Unit for questioning.
The UVF bomb attack killed 15 people over four decades ago.
After a report by the Police Ombudsman in 2011, the Chief Constable undertook a review of the case to identify any opportunities for further investigation.
The review process "identified investigative potential" in the case.
Detective Chief Inspector Justyn Galloway, who is a leading a renewed investigation into the bombing, said: "Despite the passage of time, there remain a number of opportunities to make progress."
"We will do our best to develop these lines of enquiry as thoroughly and quickly as possible."
"At the same time, I would ask those individuals who know who was involved in this attack on 4 December 1971 to talk to us."
He added: "Much has changed in the four decades since this terrible atrocity but the families of the victims and survivors continue to suffer. I would ask that anyone with information or suspicions about this bomb attack to come forward."
Anyone with information is asked to contact the police on 02891801507 or email zMIT3@psni.pnn.police.uk
